Ray Bradstone (Levesque) is the best wheel man in the business, but he is determined to go straight and be the best parent he can be to his daughter, Sally (Winter), and make amends with his ex-wife, Lynne (Gish). As Ray struggles to find honest work, his old bank-robbing crew, led by Phillip Larue (Corrigan), offers him one last job. He agrees at first, but changes his mind at the last second leaving the crew without a driver. Ray decides instead to serve as a chaperone for Sally's school field trip. When the robbery goes awry, Larue blames Ray and chases the school bus all the way to the Museum of Natural History in New Orleans. Ray must deal with Larue, while supervising Sally's class on what becomes one of the craziest school trips ever.

While working in a dam in Africa, the American hydraulic engineer Tom Newman brings his family to spend a couple of days in the Leopard's Rest Lodge. His fourteen year-old daughter Jessica is having friction with her stepmother Amy since she does not accept the divorce of her parents. On the next morning, Amy, Jessica and her brother David go in a game drive with a ranger while Tom goes to the dam. While driving off-road, David asks the ranger to stop the jeep to go to the "toilet", and unexpectedly they are attacked by a group of starving lions that kill and eat the ranger. Amy, Jessica and David are trapped in the jeep and stalked by the wild lions. When Tom returns to the hotel and finds that his family has not returned from the game, he asks for help to the experienced hunter and guide Crawford and together they seek Tom's family.